Cancer is a complex disease resulting from the interplay between the tumor cell and its microenvironment, featuring impaired apoptosis and activation of quiescent blood vessels to induce neovascularization to support metastasis. Two of the yet unmet needs in anticancer therapy are how to restore apoptosis and to abrogate metastatization.
We identified first-in-class OPA1 inhibitors with anti-cancer properties to overcome drug resistance, e.g., to Venetoclax and VEGF ligands, and thus treat cancer such as acute amyloid leukemia (AML) by specific induction of apoptosis and restriction of cancer angiogenesis.
OPA1 is mitochondrial dynamin like GTPase upregulated in several cancers where it prevents apoptosis, and its expression is correlated unfavorable prognosis. It is required for cancer angiogenesis and is responsible for Venetoclax resistance in AML.

TRL (Technology Readiness Level)

Lead Optimization/Preclinical





Download the brochure

  • New anti-tumoral approach: peptides targeting the hexokinase 2 protein

    Current antineoplastic treatments are not sufficient to cure cancer, in part due to lack efficacy and/or selectivity. Further, they often display significant side effects calling for new therapeutic approaches. The invention consists in the design, realization and administration of peptides[...]

  • A compound to mitigate the cytokine storm

    The body’s inflammatory response to fight infections and in tissue repair processes is crucial for normal functioning of the body. Yet, if not controlled, it can cause severe injury to the human body, as occurs during cytokine storm, a potentially[...]

  • CuRE – Copper complexes as novel anticancer agents

    Although platinum-based drugs, such as cisplatin, have achieved great success in cancer treatment and are presently enclosed in the majority of clinical protocols for the management of solid malignancies, their use are associated with significant drawbacks such as severe toxic[...]

Subscribe to newsletter

Follow the activities promoted by UniSMART Foundation