Accurate diagnosis and typing of Amyloidosis, a group of diseases where the abnormal protein, called amyloid, builds-up in the organs and interferes with their normal function, is of paramount importance in order to determine the appropriate therapeutic intervention.
Current methods for diagnosis of amyloidosis are lengthy, labor and cost intense, lack precision leading to both, false positives and false negatives. Additionally, significant quantity of biological material is required. Thus, there is a need for a simple diagnostic test, that would allow for quicker and more precise diagnosis of amyloidosis.
We have developed a method for diagnosis and chemical typing of amyloidosis. The invention consists of lysis buffer and procedure for protein extraction, followed by SDS-PAGE and immunoblot analysis.
This micro-extraction method was validated for cardiac amyloidosis but can also be applied to different proteins and tissues.

TRL (Technology Readiness Level)

TRL 6 / 9

Inventors

Castellani
Chiara

Angelini
Annalisa

Valente
Marialuisa

Fedrigo
Marny

Thiene
Gaetano

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PoC@Unipd project 2022

With the aim of supporting the competitiveness of businesses by enhancing industrial properties, the Ministry for Economic Development (MISE) has published a call for the establishment of patent enhancement programs, through funding of Proof of Concept (PoC) projects by Italian Universities, Public Research Institutions (EPR), and Scientific Institutions for Research, Hospital and Healthcare (IRCS).

Purpose of the call is establishing TRL (Technology Readiness Level) enhancement paths for technologies patented during academic research, and create the conditions to turn them into strategic opportunities for the business world.

After careful examination of the project proposals received by the Ministry Evaluation Committee, the University of Padua was authorized to develop 8 PoC projects. The projects were selected by the University through an internal call and the program took the first steps in December 2023. From that moment on, the PoC Team started to work to validate the relevant technologies. 

The academic work team has been flanked by an external Expert Committee, comprising top scientific and professional resources (investors and entrepreneurs), capable of providing a respected standpoint on all strategic and planning choices.

UniSMART – Fondazione Università di Padova was tasked with managing the enhancement of the results of 8 projects, through its highly qualified, innovation-oriented staff, in the different PoC project sectors.

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