The body’s inflammatory response to fight infections and in tissue repair processes is crucial for normal functioning of the body. Yet, if not controlled, it can cause severe injury to the human body, as occurs during cytokine storm, a potentially fatal chain reaction that can be generated, for example, following serious forms of infection, such as SARS-CoV-2 or sepsis.
Despite the progress in developing novel strategies to manage the immune response, the drugs that could efficiently prevent a steep surge in cytokines are still lacking.
We have identified a known compound that by blocking the membrane receptor PAR-2, is able to mitigate the cytokine storm, especially in patients with severe infections such as those due to COVID-19.

TRL

Lead Optimization/Preclinical

Inventors

Patrizia
Pontisso

Alessandra
Biasiolo

Andrea
Martini

Laura
Cendron

Monica
Chinellato

Santina
Quarta

Mariagrazia
Ruvoletto

Cristian
Turato

Gianmarco
Villano

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