The body’s inflammatory response to fight infections and in tissue repair processes is crucial for normal functioning of the body. Yet, if not controlled, it can cause severe injury to the human body, as occurs during cytokine storm, a potentially fatal chain reaction that can be generated, for example, following serious forms of infection, such as SARS-CoV-2 or sepsis.
Despite the progress in developing novel strategies to manage the immune response, the drugs that could efficiently prevent a steep surge in cytokines are still lacking.
We have identified a known compound that by blocking the membrane receptor PAR-2, is able to mitigate the cytokine storm, especially in patients with severe infections such as those due to COVID-19.

TRL (Technology Readiness Level)

Lead Optimization/Preclinical

Inventors

Patrizia Pontisso

Alessandra Biasiolo

Andrea Martini

Laura Cendron

Monica Chinellato

Santina Quarta

Mariagrazia Ruvoletto

Cristian Turato

Gianmarco Villano

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