Enzymatic Approach to Mapping Cell–Cell Interactions in Complex Populations
In recent years, the study of cell–cell interactions has become essential for understanding complex biological processes, from immune responses to tumor progression and viral infections. Current methods, however, cannot simultaneously analyze interactions between heterogeneous cell populations or precisely identify the...
An Optimized Closed-Loop Deep Brain Stimulation for Personalized Parkinson’s Treatment
Deep Brain Stimulation (DBS) is a treatment for Parkinson’s Disease that sends targeted electrical impulses to specific brain areas to manage motor symptoms. Unlike conventional systems that provide constant stimulation without adapting to real-time brain activity, closed-loop DBS adjusts stimulation...
Enhanced Multiplexing in Single-Cell Imaging Using 2D Nanolabels
Single-cell analysis is essential for understanding complex biological systems, but conventional methods like flow cytometry are constrained by spectral overlap and limited detection channels. While mass cytometry (CyTOF) addresses these issues using metal isotopes, its multiplexing capacity is capped by...
Ratiometric biosensor for the measurement of extracellular ATP
Current methods for measuring extracellular ATP (eATP) face several limitations, including interference from sample handling, reliance on transfection efficiency, and the inability to monitor real-time changes at the plasma membrane. The present invention addresses these challenges by introducing a flexible...
Device for Enhancing Brain Signal Patterns in Neural Interface Robot Control
Neural interfaces are an innovative technology for controlling external devices such as prosthetics and assistive robots. However, they are limited by low bit-rate communication and inaccurate decoders, often leading to misinterpretation of user intentions. Additionally, the current approach of using...
A Method for Allocation of Fenestrations in Patient-Specific Aortic Endografts
Fenestrated aortic endografts are used to treat aneurysmal aortic pathologies. These devices feature fenestrations at the origin of the renal and visceral arteries to preserve their patency. Traditionally, manufacturers determine the precise location of these fenestrations through specific measurements and...
Method for the automatic tracking of the fascial system displacement in ultrasound videos for objective site-specific evaluation and personalized treatment planning and prevention
The proposed algorithm has the capability to qualitatively and quantitatively evaluate the gliding between the multiple substrates of the fascial system as a biomarker for a variety of different clinical conditions (e.g. low back pain) before-during-after treatment and in follow-up....
Dynamometric handrimfor the telemetric measurement of wheelchair push biomechanics
In response to a longstanding need for accurate measurement of forces applied to wheelchair handrims, a groundbreaking telemetric system has been developed, marking a significant advancement in assistive technology. This innovative system, utilizing three biaxial load cells, offers precise real-time...
Tool for the selective section of the transverse processes of the cervical vertebrae
The patented tool allows access to the transverse foramen contents by partially dissecting the transverse process of the cervical vertebrae. In this way, the effective isolation of the vertebral vessels contained therein is allowed. In medical, surgical, and veterinary sciences,...